应用案例 Application Case

Mouse lymphatic system imaging (Nat. Commun., 2019, 10, 1058)
Mouse whole body imaging(Nat. Commun., 2020, 11, 3102)
Fluorescence imaging after allograft islets in vivo (Angew. Chem. Int. Ed. , 2023, 135, e202301696)
Mouse brain imaging (J. Am. Chem. Soc. 2019, 141, 49, 19221–19225)
Fluorescence imaging of mouse colitis (Angew. Chem. Int. Ed., 2021, 60, 26337 –26341)
Fluorescence imaging of limb blood vessels in mice (Angew. Chem. Int. Ed., 2018, 57(25), 7483-7487)
Dual imaging of mouse liver and vessels (Angew. Chem. Int. Ed. , 2022, 61, e202117436)
Real-time pH detection at tumor in mice (Angew. Chem. Int. Ed., 2021, 60(10), 5091-5095.)
Dual imaging of mouse gut and blood vessel (Angew. Chem. Int. Ed., 2023, e202311883)
Dual imaging of tumor and surrounding vessels in mouse (ACS Appl. Bio Mater. 2022, 5, 2935−2942)
Dual imaging of tumor and surrounding vessels in mouse (Angew. Chem. Int. Ed. , 2022, 61, e202114)
Dual bioluminescence imaging of mouse lymphatic and vascular (Angew. Chem. Int. Ed., 2022, 61, e202203851. )
Dual imaging of mouse brain vessels and skull implants (Nano Lett., 2022, 2, 783–791)
Dual imaging of blood vessel and lymphatic system in mouse hind limb (Nat. Mater., 2021, 20, 1571–1578)
Multiplex imaging of blood vessels, bones and organs in mouse (Anal. Chem. 2022, 94, 3661−3668)
NIR-II microscopic cell imaging (Nat. Mater., 2021, 20, 1571–1578)
NIR-II microscopic brain vessel imaging (Nano Lett. 2023, 23, 10, 4548–4556)
Dual imaging of neutrophils and blood vessels (Nat. Nanotechnol., 2023, 18, 1195-1204)
Dual imaging of blood vessels and elastic fibers (Nat. Nanotechnol., 2023, 18, 1195-1204)
Fluorescence lifetime imaging of mouse organs (Angew. Chem. Int. Ed. , 2021, 60, 23545 –23551)
Multi-channel fluorescence lifetime imaging ( Nat. Nanotechnol., 2018, 13, 941-946)
Dual bioluminescence imaging of tumor and blood vessels ( Nat. Commun., 2020, 11, 4192)
X-ray activated long afterglow angiography (Nat. Nanotechnol, 2021, 16, 1011–1018)
Chemiluminescence imaging of arthritis in mice (J. Am. Chem. Soc. 2022, 144, 33, 15391-15402 )

Monitoring focused ultrasound opens blood-brain barrier
Real-time imaging of blood flow in mouse hindlimbs
Lymphatic drainage imaging in living mice
Monitoring gastrointestinal motility in living mice
Simultaneous dynamic monitoring of arterial vasoconstriction in mice
Multiplexed dynamic tracking of neutrophil behavior in acute inflammation
In vivo microscopy imaging of tumor cell movement in mouse brains
Fluorescence-guided surgical navigation

软件支持 Software Support

The users of Digital Biotech include many well-known universities, scientific research institutions and hospitals in China, the United States, Europe, etc. Our technology and products provide strong support for their scientific research projects and medical experimental research.

Intensified Light Field for image acquisition and mechanical control

IMAGEBLOCKS for data processing

Labview for fluorescence lifetime data processing

机械支持 Mechanical Support

Customized mechanical design

Two different lens enable to adjust the imaging field of views.

The excitation light source can be easily switched to meet the needs of multiple excitation.

Autofocus through precise algorithms.

Multiple excitation with uniform power density.

Customized translation stage that can be moved in XYZ directions.

Customized accessories service

Anesthesia system (optional): To enable long-term anesthesia of small and medium-sized animals during the experiment.

Temperature control platform: To ensure that the body temperature of small animals (especially nude mice, etc.) is normal, and minimize the impact of low temperature environment on the final experimental data.

Server: To install software for data acquisition and processing.